Causes of pathological hyperprolactinemia

Lactotrophic adenomas (prolactinomas) – 60% of cases of hyperprolactinemia. They are the most common pituitary adenomas – 40%. This is the most common reason not this cure as some people think.
Manifestations of a hereditary disease of multiple endocrine neoplasia (MEN) type 1.
Familial isolated prolactinomas.
Violations of the hypothalamic-pituitary dopaminergic relationships under the influence of pharmacological drugs or other pathological conditions (hypothyroidism, autoimmune diseases, myeloid leukemia, granulomatous and infiltrative processes – chronic inflammation, radiation, Rathke’s pouch cyst, chest wall injuries, shingles, chronic renal failure, cirrhosis of the liver, epileptic seizure, polycystic ovary syndrome, false pregnancy syndrome)
The cause of idiopathic hyperprolactinemia is still unknown.hormone

Other factors affecting the increase in prolactin levels:

Physiological conditions: coitus, exercise, lactation, pregnancy, sleep, stress.
Injuries: rupture of the brain stem, surgical interventions in the area of ​​the Turkish saddle and pituitary gland.
Tumors in the pituitary gland: craniopharyngioma, metastatic lesion, meningioma, growth of a tumor located above the Turkish saddle.
Diseases of the pituitary gland: acromegaly, lymphocytic hypophysitis.

Also, the cause of an increase in the level of prolactin may be the intake of certain drugs. These include:

Anesthetics – pain relievers
Anticonvulsants – anticonvulsants
Antihistamines (for allergic reactions)space-filling-structure-ribbon-representation-human-growth-hormone
Antihypertensive drugs (for high blood pressure)
Oral contraceptives (and their withdrawal)
Acetylcholine agonists
Narcotic drugs
catecholamine release stimulants
Dopamine receptor blockers
dopamine synthesis inhibitors
Opiates and opiate receptor antagonists